Description
With today's focus on targeted and minimally invasive therapies, photodynamic therapy (PDT) is now being studied and used to combat many disease states and to investigate critical biological questions. This groundbreaking resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT - photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches. Moreover, it gives you an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases.
Table Of Contents
Part One. Basic Principles and TechniquesPhotosensitizers. Photochemical Mechanisms. Aminolevulinic Acid. Light Sources and Light Dosimetry. Photosensitizer and Oxygen Dosimetry. Photodynamic Diagnosis. Part Two: Cell Death and Signaling Pathways.PDT and Oxidative Stress. Vascular Targeting and PDT. Targeted Photosensitizer. Nanotechnology and PDT. PDT and Metastasis. PDT and Inflamation. PDT and Cellular Immunity. Metronomic PDT. Photochemical Internalization. Antimicrobial PDT. ; Part Three: Preclinical and Clinical ApplicationsPDT for Infectious Disease. PDT in Dentistry. PDT for Cardiovascular Disease. PDT in Ophthalmology. PDT in Dermatology. PDT in Gastrointestinal Cancer. PDT for Mucosal Dysplastic Lesions. PDT for Brain Cancer. PDT for Prostate Cancer. PDT for Head and Neck Cancer. Intraperitoneal PDT.;
Author
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Michael R. Hamblin
Michael R. Hamblin is a principal investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital and an associate professor of dermatology at Harvard Medical School. He was trained as a synthetic organic chemist and received his Ph.D. from Trent University in England. He has published over 85 peer-reviewed articles, over 150 conference proceedings, book chapters and International abstracts and holds 8 patents.
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Pawel Mroz
Pawel Mroz is a research fellow at the Wellman Center for Photomedicine, Massachusetts General Hospital. Dr. Mroz is currently conducting research in the area of Photodynamic therapy (PDT) a new, cutting-edge approach for treating cancers and other diseases. Dr. Mroz is a graduate of the Medical University of Warsaw, Poland.