This groundbreaking resource offers you an up-to-date account of the pioneering activity pushing new boundaries in the emerging area of inorganic nanoprobes and their use in biology and medicine. Written and edited by leading experts in the field, this unique book places particular emphasis nanoprobes made of luminescent semiconductor nanocrystals (quantum dots or QDs) and magnetic nanoparticles (MNPs). You find an insightful discussion on the synthesis, characterization, and analysis of the unique properties of luminescent QDs and MNPs. Moreover, this in-depth volume covers assay design and detection, including discussions on the design and implementation of in vitro assay studies using both fluorescence emission and magnetic contast. You also learn how to use luminescent QDs to design fluorescence resonance energy transfer (FRET) investigations. Further, this cutting-edge book looks at the use of QDs and magnetic nanoparticles for live cell imaging and intracellular sensing. You gain a thorough understanding of membrane labeling, means of delivery QD and MNP Cargos inside live cells, the use of infrared emitting QDs for tissue imaging, deep tissue imaging with MNPs based on magnetic contrast, and toxicity issues associated with the use of inorganic probes to live cells and tissue.
Section I: Synthesis, Characterization. Colloidal Quantum Dots: Synthesis, Photophysical Properties and Biofunctionalization Strategies. Colloidal Chemical Synthesis of Organic-Dispersible Uniform Magnetic Nanoparticles. Section II: Use of QDs and AU-NPs Conjugated to Biomolecular Receptors for Sensor Design and Imaging. Peptide-Functionalized Quantum Dots for Live Diagnostic Imaging and Therapeutic Applications. Resonance Energy Transfer-Based Sensing Using Quantum Dot Bioconjugates. Intracellular Imaging and Sensing with QDs. Single Particle Investigation of Biological Processes Using QD-Bioconjugates. Exploring and Understanding the Toxicity of QDs and Nanoparticles to Cells and Tissue. Chemical and Biological Sensing Based on Gold Nanoparticles. Plasmon-Resonant Gold Nanorods: Photophysical Properties Applied Toward Biological Imaging and Therapy. Section III: Use of Magnetic Nanoparticles for Contrast Imaging and Sensing. Design and Use of Magnetic Nanoparticles as Constrast Agents for Tissue and Cell Imaging. Magnetic Nanoparticles assisted Cellular MR Imaging and their Biomedical Applications.; To view complete TOC:; Click Google Preview button under book title above, then click on Contents tab.;
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Jinwoo Cheon
Jinwoo Cheon is a professor in the Department of Chemistry at Yonsei University, Korea, where he is the director of the Convergence Nanomaterials System in the National Research Library. He holds an M.S. in chemistry from Yonsei University and a Ph.D. from the University of Illinois, Urbana-Champaign.
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Hedi Mattoussi
Hedi Mattoussi is the principle investigator in the Institute of Nanoscience at the U.S. Naval Research Laboratory (NRL). His activity at NRL focuses on the development of inorganic nanoparticles and their interfacing with biological systems. Dr. Mattoussi earned his Ph.D. in condensed matter physics from Pierre and Marie Curie University, Paris.