Written and edited by recognized experts in the field, the new Artech House Methods in Bioengineering book series offers detailed guidance on authoritative methods for addressing specific bioengineering challenges. Offering a highly practical presentation of each topic, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. Providing alternatives to animal testing is one of the hottest topics in biomedical research, and this groundbreaking volume addresses this critical issues head on. This unique book presents techniques and methods at the forefront of scientific research that have the potential to replace certain whole animal tests. Moreover, this book provides a platform where other widely accepted techniques and scientific advancements can be collated into a concise set of methods that can be implemented within both academic and industrial communities.
Current Methods for Prediction of Human Hepatic Clearance Using In Vitro Intrinsic Clearance -Introduction. Materials. Methods. Data Acquisition, Anticipated Results, and Interpretation. Discussion and Commentary. Summary. ; Use of Permeability from Cultured Cell Lines and PAMPA System and Absorption from Experimental Animals for the Prediction of Absorption in Humans -Introduction. Materials. Methods. Data Acquisition, Anticipated Results, and Interpretation. Discussion and Commentary. Summary. ; Aggregating Brain Cell Cultures for Neurotoxicity Tests -Introduction. Experimental Design. Materials. Methods. Anticipated Results. Discussion and Commentary. Application Notes. Summary Points. ; Approaches Towards a Multiscale Model of Systemic Inflammation in Humans -Introduction. Materials. Methods. Results. Conclusions. ; A Liposome Assay for Evaluating the Ocular Toxicity of Chemicals -Introduction. Experimental Design. Materials. Methods. Data Acquisition, Anticipated Results, and Interpretation. Discussion and Commentary. Application Notes. Summary Points. ; Prediction of Potential Drug Myelotoxicity by In Vitro Assays on Hematopoietic Progenitors -Introduction. Experimental Design. Materials. Methods. Data Acquisition, Anticipated Results, and Interpretation. Discussion and Commentary. Application Notes. Summary Points. ; Epigenetically Stabilized Primary Hepatocyte Cultures: A Potential Sensitive Screening Tool for Nongenotoxic Carcinogenicity -Introduction. Experimental Design. Materials. Methods. Data Acquisition. Anticipated Results and Interpretation. Discussion and Commentary. Application Notes. Summary Points. ; A Statistical Method to Reduce In Vivo Product Testing Using Related In Vitro Tests and ROC Analysis -Introduction. Experimental Design. Materials. Methods. Results. Discussion and Commentary. Summary Points. ; Application of the Benchmark Approach in the Correlation of In Vitro and In Vivo Data in Developmental Toxicity -Introduction. Materials and Methods. Discussion and Commentary. ; Three-Dimensional Cell Culture of Canine Uterine Glands -Introduction. Materials. Methods. Anticipated Results. Discussion and Commentary. Application Notes. Summary Points. ; Markers for an In Vitro Skin Substitute -Introduction. Experimental Design. Materials. Methods. Anticipated Results. Discussion and Commentary. Application Notes. Summary Points. ; 3D Culture of Primary Chondrocytes, Cartilage, and Bone/Cartilage Explants in Simulated Microgravity -Introduction. Experimental Design. Materials. Methods. Anticipated Results. Discussion. Application Notes. Summary Points. ; Alternatives for Absorption Testing -Introduction. Materials. Methods. Results and Discussion. Discussion of Pitfalls and Troubleshooting. Summary. ; A 3D Model of the Human Epithelial Airway Barrier -Introduction. Experimental Design. Materials. Methods. Anticipated Results. Discussion and Commentary. Application Notes. Summary Points. ; Experimental Wear Assessment of Tibial Inserts for Total Knee Replacement -Introduction. Experimental Design. Materials. Methods. Anticipated Results. Discussion and Commentary. Application Notes. Summary Points.; Acknowledgments. References. About the Editors. Index ;
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Tim Maguire
Tim Maguire works at a startup company, where he is pursuing the creation of in vitro drug screening systems, integrating optimized human hepatocyte cultures with microfluidic systems. He holds a B.S. in chemical engineering and a Ph.D. in biomedical engineering, both from Rutgers University.
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Eric Novik
Eric Novak works at a startup company and is involved in all aspects of development and commercialization of patented microfluidic, cell-based platforms for use in drug discovery and development, consumer and industrial product testing, and related fields. He holds a B.S. and a Ph.D. in biomedical engineering from Rutgers University.